Ambien And Depression: How Are They Related?

What Is Ambien?

Ambien is the brand name of the generic drug zolpidem. It is a short-acting non-benzodiazepine hypnotic that concentrates the neurotransmitter GABA or gamma-aminobutyric acid. It is primarily used to treat insomnia and works immediately in as early as 15 minutes after taking.

The molecular structure of Ambien is different from traditional benzodiazepines but have somewhat similar sedative effects. Ambien and depression have been related due to the fact that high amounts of the drug can cause a variety of mental symptoms and side effects. Other unlabeled uses of the drug include the treatment of restless leg syndrome, reversal of stimulants like amphetamines and akinetic mutism.

How Ambien Works

Ambien binds with GABAA receptors and modulates it to increase affinity with GABA. As GABA and the receptors increased in compatibility, sleep quality and duration are then improved significantly.

Specifically, the chloride channel macromolecular complex is responsible for wakefulness, sleepiness and muscle relaxation. The action of GABA is to support how interneurons control specific functions in the brain including muscle activity. Overall, depending on the dosage and usage of Ambien, patients can experience wakefulness or be sedated.

There are controversies surrounding the sleep-aiding effects of zolpidem. A number of reports have pinpointed to the drug causing deaths due to vivid dreams, nightmares and sleepwalking. It seems that during sleep, there is hyperactivity in the brain which acts jointly with muscle control.

Common Side Effects

There are side effects that should be watched out for since these could eventually lead to major depression. It is unusual to experience worsening sleep problems, frequent depressed mood or ideations of suicide or self-mutilation, lowered inhibitions, unusual lack of fear, aggression, frequent agitation with no apparent reason, hallucinations, loss of self, loss of interest, daytime drowsiness, amnesia, gastrointestinal upsets and muscle pain.

Drugs like itraconazole, rifampin, fluoxetine and sentraline should not be taken simultaneously with Ambien to avoid complications. Substances like alcohol and caffeine should also be cautiously taken.

Ambien and Depression

Depression from Ambien can be due to overdose or resulting imbalances from underlying conditions that the user may already have. Chemical imbalances in the brain due to the potent actions of the drug can occur.

Overdose, drug and substance interaction and long term use are all predisposing factors that can cause GABA and its respective receptors to malfunction thereby causing altered states of depression due to abnormal neurotransmitter activity.

What to Watch Out For

Depression caused by Ambien can be avoided if early symptoms are reported in order to discontinue the medication. Hallucinations, slurred speech, agitation, restlessness, dizziness, confusion, memory loss and sleep disturbances are all early manifestations of developing depression. Should the drug be withdrawn, it is equally important for the individual to continue doing activities that promote mental wellness and emotional stability.

Socialization techniques, a healthy diet, adequate rest periods and multivitamins can help a lot in keeping the brain and neurotransmitters in good condition. Do not take antidepressants with the intent to counter initial symptoms of depression. Always consult a physician before taking any new medication and to discuss any concerns about Ambien and depression.